L'elettroagopuntura modula i livelli degli ormoni riproduttivi (sessuali) in pazienti con insufficienza ovarica primitiva: risultati da uno studio prospettico osservazionale

Vi suggerisco un articolo conservato presso la National Library of Medicine ed indicizzato da Pub-med. Di seguito trovate l'abstract ed il link a PubMed.

ABSTRACT.

Per indagare l'effetto dell'elettroagopuntura sui livelli sierici di FSH, E2 e LH, donne con insufficienza ovarica primitiva (POI) sono state trattate con elettroagopuntura una volta al giorno, 5 volte a settimana per le prime 4 settimane; a giorni alterni, 3 volte a settimana, per i due mesi seguenti e poi sono state seguite per 3 mesi. I livelli sierici di E2, FSH e LH sono stati misurati al momento iniziale, alla fine del trattamento e durante il followup. Un totale di 11 donne con POI sono state incluse in questo studio prospettico osservazionale (prospective consecutive case series study). A confronto con il livello iniziale, la quantità di E2 nel siero delle pazienti era aumentata, quella di FSH era diminuita e quella di LH era diminuita (P=0.002, 0.001, e 0.002, rispettivamente) dopo il trattamento con elettroagopuntura e questi effetti persistevano durante il followup. Con il trattamento 10 pazienti ripresero ad avere le mestruazioni (10/11,
 90.91%),  mentre invece una paziente rimase in amenorrea. Durante il followup 2 pazienti, compresa quella che durante il trattamento era rimasta in amenorrea, riportarono assenza di mestruazioni. Occasionalmente si era verificato un dolore temporaneo e nessun altro evento avverso si era manifestato durante il trattamento. I risultati suggeriscono che l'elettroagopuntura possa ridurre i livelli sierici di FSH e LH ed aumentare il livello sierico di E2 in donne con POI con piccoli o assenti effetti collaterali; ad ogni modo ulteriori studi randomizzati controllati sono necessari.

Il titolo dell'estratto è: Electroacupuncture modulates reproductive hormone levels in patients with primary ovarian insufficiency: results from a prospective observational study.

Fate click sul titolo per seguire il link.

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L'Agopuntura nel trattamento della sindrome del tunnel carpale: un articolo del Journal of Research in Medical Sciences

"Nell'era del mouse e delle lunghe ore che passiamo al pc, assistiamo ad una vera epidemia di cosiddetta sindrome del tunnel carpale, una malattia molto fastidiosa che affligge migliaia di persone nel nostro paese e che comporta dolore alle mani, formicolii, perdita di forza, scariche elettriche, e che spesso esita nella chirurgia, che non sempre e' risolutiva, ma, anzi, spesse volte aggrava il quadro. Ecco una ricerca che rispetta tutti i criteri della scienza moderna che dimostra, senza alcun dubbio, l'utilità dell'agopuntura in questa spinosa malattia."

Acupuncture in treatment of carpal tunnel syndrome: A randomized controlled trial study

 

 

Abstract

BACKGROUND:

Carpal tunnel syndrome (CTS) is the most preva lent form of peripheral neuropathy. The efficacy of acupuncture in management of mild to moderate CTS has been investigated in limited studies with controversial results. The aim of this study was to assess the short-term effects of acupuncture in treatment of mild to moderate carpal tunnel syndrome.

METHODS:

In a randomized controlled trial study, participants were randomly assigned to either control group which night splinting, vitamin B1, B6 and sham acupuncture for four weeks were administered, or intervention group that underwent acupuncture in 8 sessions over 4 weeks and night splinting. The clinical symptoms using global symptom score (GSS) and electrophysiological parameters were assessed at baseline and four weeks after the intervention.

RESULTS:

Of 72 patients met the inclusion criteria, 64 patients actually completed the 4 week intervention and were evaluated for the outcome. There was a statistically significant difference in GSS between two arms of treatment after the intervention (p < 0.001) Using repeated measure ANOVA, the GSS in acupuncture group was significantly different after 4 weeks (p <0.001). Among electrophysiological parameters, nerve conduction velocity (NCV) was significantly different between two groups after 4 weeks (p = 0.02). Other parameters showed no statistically significant difference after intervention (p > 0.05).

CONCLUSIONS:

Our findings indicated that the acupuncture can improve the overall subjective symptoms of carpal tunnel syndrome and could be adopted in comprehensive care programs of these patients.

KEYWORDS: Carpal Tunnel Syndrome, Acupuncture, Global Symptom Score, Electrophysiological Parameters

Carpal tunnel syndrome (CTS) is the most prevalent form of peripheral entrapment syndrome, characterized by numbness, tingling, hand pain, and muscular dysfunction.1 The incidence of this disorder is 1-3 cases per 1000 subjects per year in United States and can occur in all ages2 with more incidence in women.3

Several interventions both conservative and surgical treatments are proposed for treatment of CTS.4According to the recommendations of American Association of Orthopedic Surgeons (AAOS), conservative treatments include splinting, local steroid injection, ultrasound, and oral steroids that are effective in patients with mild to moderate symptoms. Surgery is suggested if conservative treatments fail.5

Among several interventions for pain management, acupuncture has received special attention. Acupuncture is the most familiar complementary and alternative medicine, especially in Chinese medical treatments.6 The Acupuncture and carpal tunnel syndrome efficacy of acupuncture in management of mild to moderate CTS has been investigated in limited studies.79

A recent randomized controlled trial study compared the efficacy of acupuncture with night splinting for CTS and found that electro-acupuncture was as effective as night splinting in management of symptoms in mild to moderate CTS.10 Yang et al. showed that short-term acupuncture treatment is as effective as oral prednisolone in mild to moderate CTS.11 But recalculation of the mean difference by a systematic review showed no statistical difference (p = 0.15), except for distal motor latency in terms of NCS.12

In 2010, one systematic review assessed the effectiveness of acupuncture in CTS treatment and found that the existing evidence is not convincing enough to suggest that acupuncture is an effective therapy for CTS.12 However, National Institute of Health (NIH) confirmed acupuncture for management of mild to moderate CTS,13 but there is still controversy in its effectiveness.14 ,15 The aim of this study was to assess the short term effects of acupuncture in treatment of mild to moderate CTS.

Methods

This was a randomized controlled trial study undertaken in physical and rehabilitative medicine outpatient clinics in Alzahra and Kashani Hospitals, Isfahan, Iran. Diagnosis of patients was made based on at least one of the following clinical criteria which were confirmed by Tinel's and Phalen's tests:3 1) Numbness and tingling in the thumb, index finger, middle finger and ring finger (the region innervated by median nerve); 2) Provocation of symptoms by repetitive actions of the hand or wrist; 3) Mitigation of symptoms by changing hand posture or shaking the wrist; 4) Nocturnal symptoms. The diagnosis of all patients with clinically diagnosed CTS, was confirmed by the presence of 1 or more of the following standard electrophysiological criteria:2 1) prolonged distal motor latency (DML ≥ 4.2 ms); 2) Prolonged antidromic distal sensory latency (DSL) to the second digit (≥3.6 ms); 3) Reduced wrist-palm sensory nerve conduction velocity (W-P SNCV < 40 ms).

In this study, mild CTS was attributed to the patients with decreased conduction velocity over the palm-wrist segment and delayed DSL, with or without normal median sensory nerve action potential (SNAP) amplitude. Moderate CTS was attributed to patients with abnormally delayed DML and DSL with either decreased median SNAP amplitude.16

Exclusion criteria were as follows: Severe CTS; presence of either fibrillation potentials or reinnervation on needle electromyography (EMG) in the abductor pollicis brevis (APB); experiencing symptoms less than 3 months before the study or symptoms improving during the one month initial observation period (to exclude patients who might have spontaneous resolution of symptoms); clinical and electro-diagnostic criteria of associated conditions that could mimic CTS or interfere with its evaluation, such as cervical radiculopathy, proximal median neuropathy, or significant polyneuropathy; evidence of predisposing conditions such as pregnancy, diabetes mellitus, rheumatoid arthritis, hypothyroidism and trauma; previous unfavorable experience of acupuncture or bleeding history; cognitive disorders and unwillingness to participate in the present study.

Between June 2010 and February 2011, participants were randomly assigned using computerized random numbers to control or treatment groups. Night splinting, vitamin B1, B6 and sham acupuncture was administered in control group for four weeks. For sham acupuncture, participants received a non-skin penetrating pricking sensation using a previously validated sham procedure.17 The needles inserted at similar body locations as the true acupuncture group and the length of time was similar for needle insertion. Intervention group underwent acupuncture in 8 sessions over 4 weeks and also night splinting. Acupuncture consisted of 8 sessions that were 60 minutes each in duration, administrated over 4 weeks (2 sessions per week). Acupuncture was done with 0.25*40 mm size gauge in fixed and classic acupuncture points (PC-7 [Daling], PC-6 [Neiguan] for each patient. All participants were blindfolded during each treatment to prevent patient knowledge of treatment assignment and true and sham acupuncture were done by an expert acupuncturist.

The clinical symptoms were assessed using Global Symptom Score (GSS) at baseline and after 2 and 4 weeks of intervention. This scoring system rates clinical symptoms from 0 (no symptoms) to 10 (very severe symptoms) in the following 5 areas: Pain, numbness, tingling, weakness/clumsiness, and nocturnal awakening. Therefore, the maximum score was 50 that indicated most severe symptoms and the minimum score was 0 that showed absence of symptoms.18,19

Electrophysiological parameters were assessed as the secondary outcome at baseline and four weeks after the intervention. These parameters included DML (distal motor latency), sensory NCV (nerve conduction velocity) and DSL (distal sensory latency). All tests were done using an Advantage EMG machine (Medelec synergy, UK). Nerve conduction studies were performed by an experienced electro-myographer who was blinded to random assignment. Surface stimulation in sensory and motor nerve conduction studies was done using standard methodology.16 The electromyo-grapher monitored the hand temperature using an adhesive surface thermistor on the thenar eminence to ensure the hand temperature between 32°C and 34°C.

During the sensory nerve conduction studies, the median sensory nerve fibers were stimulated antidromically with 0.05 ms square pulse at midpalm and wrist with a distance of 7 cm and 14 cm from the recording ring electrode looped around the proximal interphalangeal joint of the third digit. The reference ring electrode was placed around the distal interphalangeal joint. During the motor nerve conduction studies, the median motor nerve fibers were stimulated with 0.05 ms square pulse at the wrist at a distance of 8 cm proximal to the recording electrode placed over the motor point of the thenar muscles. The reference electrode was placed over the dorsal aspect of the first metacarpophalangeal joint.

This trial was registered in the Iranian Randomized Controlled Trial Registry with number IRCT201108174242N2.The design of the study was approved in Ethics Committee of Vice Chancellor for Research, Isfahan University of Medical Sciences (project no 389393). All participants received trial information and provided written informed consent. In addition, the confidentiality of all information was carefully managed by researchers.

 

Statistical Analysis

The characteristics of subjects were presented as mean ± SD for the continuous variables and percentage for attributes measured on an ordinal or nominal scale. The independent sample t-test was used to compare the clinical characteristics (nerve conduction and global symptom score) between the two groups at baseline and after the intervention. Repeated measures analysis of variance (ANOVA) was performed to compare GSS between groups at baseline, 2 and 4 weeks after the intervention. The comparison of electrophysiological parameters in the two groups was done via paired sample t-test. All tests of hypotheses were 2-tailed and the level of significance was set at 0.05. All statistical analyses were performed using SPSS Version 19.0 for Windows.

Results

In general, 72 patients fulfilled the inclusion criteria and were enrolled in the study. Eight patients were excluded due to severe CTS (n=3) and evidence of predisposing conditions including diabetes (n= 2) and pregnancy (n=3). Sixty four subjects (32 patients in the acupuncture and 32 patients in the control group) actually completed the 4 week intervention and were evaluated for the outcome (64 limbs) (Figure 1).

Figure 1
Study profile

The mean age of patients in acupuncture group was 41.7 ± 9.3 years with a range of 25 to 65 years, of whom 23 patients were female (71.9%). The control group consisted of 25 females (78.1%).The mean age of these patients was 41.1 ± 9.6 years with a range of 25 to 65 years. There was no statistically significant difference in demographic data between the two groups at the start of trial (p > 0.05) indicating the success of randomization. The mean GSS at baseline was 24.1 ± 8.1 in intervention group and 23.7 ± 8.9 in control group. Baseline characteristics were balanced across treatment arms, indicating the success of randomization (p = 0.85).

Using repeated measure ANOVA, the GSS in acupuncture group was significantly different after 4 weeks (p < 0.001), whereas the control group remained at about the same level even after 4 weeks (p = 0.17). At the end of study, the mean of GSS in acupuncture group showed a progressive loss of clinical effects in comparison to control group (p < 0.001).

Among electrophysiological parameters, NCV showed statistically significant difference between two groups after 4 weeks (p = 0.02) and the acupuncture group had a significantly better improvement in NCV score (p=0.02). The mean of DML and DSL scores were not significantly different at baseline and even after 4 weeks between two arms of treatment (p > 0.05). Paired t-test showed similar results before and after the study in each group (p > 0.05). The results of GSS and electro physiologic parameters are summarized in table 1.

Table 1
The mean of Global Symptom Score and electrophysiological parameters in two groups before and after the intervention

Discussion

The aim of this study was to assess the short term effects of acupuncture in treatment of mild to moderate carpal tunnel syndrome. Our results showed that patients received acupuncture had significantly better improvement in clinical symptoms of CTS. Among electro physiologic characteristics, NCV showed improvement in the acupuncture group in comparison to the control group.

Acupuncture treatment had superior efficacy when compared to night splinting plus sham acupuncture at least in subjective symptom assessment. This result was confirmed objectively by NCV evaluation. However, acupuncture was as effective as night splinting plus sham acupuncture in respect to other electro physiologic parameters. The result of this study was in line with previous research.

A recent randomized trial study with long term follow-up (13 months) compared acupuncture versus oral steroids in management of CTS. Both groups showed more than 50% improvement in GSS at month 7 and 13. Furthermore, patients with acupuncture treatment had significantly better improvement in GSS and DML and DSL, compared to the steroid group. The results of this study showed greater efficacy of acupuncture both in symptom assessment and objective changes in nerve conduction.20

Another randomized controlled trial study compared efficacy of acupuncture with night splinting (5 weeks) for CTS and found that electro-acupuncture was as effective as night splinting in management of symptoms in mild to moderate CTS.10 Furthermore, a Chinese study showed a promising effect of needle acupuncture compared with steroid block therapy in terms of responder rate.21 A meta-analysis of acupuncture versus steroid nerve blocks confirmed this result.12

On the other hand, some evidence did not demonstrate benefit in symptom relief in acupuncture intervention when compared to placebo or control. Weinstein et al. evaluated the effect of manual acupuncture in comparison with sham acupuncture and found no statistical difference between the real and sham groups.22 Another randomized controlled trial study found no significant differences between laser acupuncture and placebo on night pain at 3 weeks of follow-up.23 A Cochrane meta-analysis reviewed twenty one trials of different conservative managements of CTS including one laser acupuncture trial study, concluded that acupuncture do not produce significant benefit.15Ineffectiveness of laser acupuncture in CTS was indicated in another systematic review.19 Both of these reviews indicated that there are limited evidence in this field.

Some studies examined the mechanism of acupuncture on CTS. Studies by functional magnetic resonance imaging (fMRI) showed that acupuncture stimulation caused a change in brain processing or a coordinated limbic response.2426 Other studies suggested that acupuncture has an anti-inflammatory and immune modulator effect.2729 Although the exact mechanism of acupuncture effects on CTS is not accurately understood, current study demonstrated effectiveness of this method in management of CTS. Two studies investigated side effects of acupuncture in CTS, indicating some side effects such as swelling and pain in right hand.30 In our study we did not detect any side effect in acupuncture or control group.

Our study, while having much strength, involved some limitations that should be considered. This study was limited due to considering short-term effects, small number of patients in each arm of treatment and more physician visits in the acupuncture group. The small sample size prevented from subgroups analyses to further elaborate the effects of acupuncture in mild and moderate CTS. Further research is recommended to determine long-term outcome and comparison of acupuncture to other conservative managements of CTS.

In conclusion, the results of this randomized controlled trial indicated that acupuncture can improve the overall subjective symptoms of carpal tunnel syndrome and could be adopted in comprehensive care programs of these patients.

Authors’ Contributions

SK was the main investigator, analyzed the data and wrote the paper. AM contributed to the study design and writing the manuscript. SH helped in designing the study, contributed to the analysis and helped in writing the final manuscript. All authors read and approved the final version of manuscript.

Acknowledgments

This study was funded by research chancellor of Isfahan University of Medical Sciences as a research project numbered 389393. Our heart-felt thanks are extended to all the patients who so graciously agreed to participate in this study. Also we greatly thank all staff of physical medicine and rehabilitation clinics for their support throughout the project.

Footnotes

 

Conflict of Interests Authors have no conflict of interests.

 

References

1. Palmer KT, Harris EC, Coggon D. Carpal tunnel syndrome and its relation to occupation: a systematic literature review. Occup Med (Lond) 2007;57(1):57–66. [PubMed]
2. Keith MW, Masear V, Chung K, Maupin K, Andary M, Amadio PC, et al. Diagnosis of carpal tunnel syndrome. J Am Acad Orthop Surg. 2009;17(6):389–96. [PubMed]
3. Bland JD. Carpal tunnel syndrome. BMJ. 2007;335(7615):343–6. [PMC free article] [PubMed]
4. Prime MS, Palmer J, Khan WS, Goddard NJ. Is there Light at the End of the Tunnel? Controversies in the Diagnosis and Management of Carpal Tunnel Syndrome. Hand (N Y) 2010;5(4):354–60.[PMC free article] [PubMed]
5. Keith MW, Masear V, Amadio PC, Andary M, Barth RW, Graham B, et al. Treatment of carpal tunnel syndrome. J Am Acad Orthop Surg. 2009;17(6):397–405. [PubMed]
6. Acupuncture: Review and Analysis Reports on Controlled Clinical Trials. Geneva: WHO; 2002. World Health Organization.
7. Naeser MA, Hahn KA, Lieberman BE, Branco KF. Carpal tunnel syndrome pain treated with low-level laser and microamperes transcutaneous electric nerve stimulation: A controlled study. Arch Phys Med Rehabil. 2002;83(7):978–88. [PubMed]
8. Freedman J. Acupuncture for carpal tunnel syndrome. Acupunct Med. 2002;20(1):39–40. [PubMed]
9. Schulman RA, Liem B, Moroz A. Treatment of carpal tunnel syndrome with medical acupuncture.Medical Acu-puncture. 2008;20(3):163–7.
10. Kumnerddee W, Kaewtong A. Efficacy of acupuncture versus night splinting for carpal tunnel syndrome: a rando-mized clinical trial. J Med Assoc Thai. 2010;93(12):1463–9. [PubMed]
11. Yang CP, Hsieh CL, Wang NH, Li TC, Hwang KL, Yu SC, et al. Acupuncture in patients with carpal tunnel syndrome: A randomized controlled trial. Clin J Pain. 2009;25(4):327–33. [PubMed]
12. Sim H, Shin BC, Lee MS, Jung A, Lee H, Ernst E. Acupuncture for carpal tunnel syndrome: a systematic review of randomized controlled trials. J Pain. 2011;12(3):307–14. [PubMed]
13. Acupuncture. NIH Consens Statement. 1997;15(5):1–34. [PubMed]
14. Ernst E. Acupuncture: what does the most reliable evidence tell us? J Pain Symptom Manage.2009;37(4):709–14. [PubMed]
15. O’Connor D, Marshall S, Massy-Westropp N. Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome. Cochrane Database Syst Rev. 2003;(1):CD003219. [PubMed]
16. Dumitro D, Amato AA, Zwarts MJ. Electrodiagnostic Medicine. 2nd ed. San Antonio: Hanley & Belfus; 2001.
17. Sherman KJ, Hogeboom CJ, Cherkin DC, Deyo RA. Description and validation of a noninvasive placebo acupuncture procedure. J Altern Complement Med. 2002;8(1):11–9. [PubMed]
18. Chang MH, Ger LP, Hsieh PF, Huang SY. A randomised clinical trial of oral steroids in the treatment of carpal tunnel syndrome: a long term follow up. J Neurol Neurosurg Psychiatry. 2002;73(6):710–4.[PMC free article] [PubMed]
19. Gerritsen AA, de Krom MC, Struijs MA, Scholten RJ, de Vet HC, Bouter LM. Conservative treatment options for carpal tunnel syndrome: a systematic review of randomised controlled trials. J Neurol.2002;249(3):272–80. [PubMed]
20. Yang CP, Wang NH, Li TC, Hsieh CL, Chang HH, Hwang KL, et al. A randomized clinical trial of acupuncture versus oral steroids for carpal tunnel syndrome: a long-term follow-up. J Pain.2011;12(2):272–9. [PubMed]
21. Cai DF. Acupuncture treatment and releasing manipulation of carpal tunnel syndrome. Traditional Chinese Medicine Information. 2007;24:56.
22. Weinstein A, Pan J, Richardson P. A controlled pilot trial of acupuncture for carpal tunnel syndrome. Clin Acupunct Orient Med. 2003;4:48.
23. Aigner N, Zöch G, Fialka Results of laser-acupuncture in carpal tunnel syndrome a prospective; randomised and blinded study. Focus on Alternative and Complementary Therapies. 1998;3(4):180.
24. Asghar AU, Green G, Lythgoe MF, Lewith G, MacPherson H. Acupuncture needling sensation: the neural correlates of deqi using fMRI. Brain Res. 2010;1315:111–8. [PubMed]
25. Napadow V, Liu J, Li M, Kettner N, Ryan A, Kwong KK, et al. Somatosensory cortical plasticity in carpal tunnel syndrome treated by acupuncture. Hum Brain Mapp. 2007;28(3):159–71. [PubMed]
26. Napadow V, Kettner N, Liu J, Li M, Kwong KK, Vangel M, et al. Hypothalamus and amygdala response to acupuncture stimuli in Carpal Tunnel Syndrome. Pain. 2007;130(3):254–66.[PMC free article] [PubMed]
27. Kavoussi B, Ross BE. The ne uroimmune basis of anti-inflammatory acupuncture. Integr Cancer Ther. 2007;6(3):251–7. [PubMed]
28. Zijlstra FJ, van den Berg-de Lange, Huygen FJ, Klein J. Anti-inflammatory actions of acupuncture.Mediators Inflamm. 2003;12(2):59–69. [PMC free article] [PubMed]
29. Takahashi T, Sumino H, Kanda T, Yamaguchi N. Acupuncture Modifies Immune Cells. Journal of Experimental & Clinical Medicine. 2009;1(1):17–22.
30. Nishimura T, Hirata H, Uchida A. Acute carpal tunnel syndrome induced by hemorrhage during acupuncture therapy. Medical Acupuncture. 2008;20(1):63–5.

Articles from Journal of Research in Medical Sciences : The Official Journal of Isfahan University of Medical Sciencesare provided here courtesy of Medknow Publications


I punti Yuan nel Ling Shu e nel Nanjing

Tanti anni fa, durante lo studio dei punti, confuso da tanta numerosità e assetato di chiarezza chiesi al mio maestro di allora Leung Kwok Po: «Leung, ma quali sono secondo te i punti più importanti?» Lui senza esitazione mi rispose i punti yuan, e me ne spiegò le ragioni. Da allora ho sempre tenuto in grande considerazione questi punti in quanto il loro contenuto di yuanqi (energia Originaria) e le loro doti di equilibrio li rendono punti preziosi nella pratica quotidiana ed è per questa ragione che oggi ho scelto questo argomento per la rubrica sui Testi Classici.

Inoltre credo che sia importante sapere che non tutti gli studiosi dei Testi Classici hanno la stessa visione di questi punti. Nella fattispecie colpisce il fatto che alcuni sostengano che il contenuto del Lingshu su questo argomento specifico sia stato stravolto da uno dei più importanti testi che sono venuti in seguito, il Nanjing, il cosiddetto Classico delle Difficoltà.

Questo non è cosa da poco considerando che comporta un uso diverso dei punti Yuan rispetto a quello che finora abbiamo imparato.

 
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Professore incaricato dell'insegnamento di Medicina Generale/ Medicina di Famiglia presso la Facoltà di Medicina e Chirurgia dell'Università degli Studi dell'Aquila
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